My Que!Fire 12/10/32 just died on me so now I have the 16/10/40 (but now wonder if I should have just gone and bought the 24/10/40). Anyway, when the 12/10/32 first came out it was packed with the OEM Toast4.1.1 which turned out to not work. There is now the 4.1.2 version that works fine. I use Toast Titainium 5 and its' peachy. If it's not that then it might be a extension conflict. It's known that the Toast Firewire extension conflicts with iTunes Firewire extension so one or the other must be disabled as use dictates. On a longshot, there are user reports elsewhere (not neccessarally QPS users) indicating potential problems interfacing with a Firewire PCI card or using a Firewire hub. If there is a hub, try using the Que!Fire connected directly into the computer. And the PCI card, your guess would be as good as mine. Cheers!