krieger, judging by the pics you posted it doesn't look like DeSpot or RemoveDirt can help too much for this situation, it just looks like a noisy capture. Have you tried one of the heavy duty denoisers like Dust or PeachSmoother, or perhaps Deen?

I've tried Deen, PeechSmooter many VD-Smoother (2D-Cleaner, Smart-Smoother, Dynamic Denoise,...). Deen removes the noise only when i set the threadhold very high. A good result could get when smoothing the LUMA. But then the pics were unsharp. Yesterday i tried DeSpot. @Bogalvator: You're right. DeSpot is not very helpfull. The very good thing while using DeSpot is the static-smoothing: pthres<p2 and tsmoth>=4 This removes many of the spots but such effect i can get when i will use temporalsmoother (i've tried also). The Problem is not that the movie is noisy. The Problem is, that some 10 frames is such a noisy frame. Other Frames are "cleaner"... But Thanks for the help